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(An active ingredient is what makes a drug work.) Viagra belongs to a group of drugs called phosphodiesterase 5 (PDE5) inhibitors. The use of VIAGRA offers no protection against sexually transmitted diseases. VIAGRA is rapidly absorbed after oral administration, with a mean absolute bioavailability of 41% (range 25–63%). The pharmacokinetics of sildenafil are dose-proportional over the recommended dose range. It is eliminated predominantly by hepatic metabolism (mainly CYP3A4) and is converted to an active metabolite with properties similar to the parent, sildenafil.
Appropriate studies have not been performed on the relationship of age to the effects of sildenafil in children younger than 1 year of age. Other medications can affect the removal of sildenafil from your body, which may affect how sildenafil works. Examples include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, erythromycin), mifepristone, rifampin, ritonavir, among others. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. In the rare event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and get medical help right away, or permanent problems could occur.
Doctors typically start with the lowest dose that is effective in treating erectile dysfunction. One important drug class to keep in mind is the nitrates