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In fact, 14% of all products seized by CBP in 2019 were wallets and handbags. This adds up to an MSRP of $212,781,760 for seized import handbags alone. However, you'll find street vendors selling them in any of the larger tourist centres.
I have mostly seen stuff about fake Rolex watches and that was mostly about how to avoid being ripped off. Fake products are a big problem to the companies that make the expensive stuff, and they have to defend themselves against the fakers in any way they can. So if it is a handbag that was sold as a replica - that is you knew that it was not a genuine bag and it doesn't have the logo on it, you would probably be OK. High quality or super fake replicas should very closely mimic their authentic counterparts in terms of craftsmanship, quality of materials, and overall appearance or look. I have no interest in carrying a poorly crafted replica and only seek to buy designer replicas that are as close to the real thing as possible. There are many options when it comes to deciding where you should buy a replica bag from.
There are places (real stores, not just guys on the street) especially in florence that sell wallets, handbags, belts, made of beautiful Italian leather. They aren't Fendi, Prada and such, but they can be very nice, and won't break the bank for a gift for your sister. In Venice you could get her a beautiful piece of Murano glass, albeit a very small one